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Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications

1 Jul 2025

Abstract excerpt

Histone lactylation, as a common post-translational modification (PTM), is crucial in diseases. Aberrant histone lactylation has been linked to disease pathogenesis, thus positioning it as a therapeutic target. This review summarizes the bidirectional relationship between histone lactylation and diseases, emphasizing how Traditional Chinese medicine (TCM) regulates lactate levels to restore histone lactylation...

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PMID: 40756263
DOI: 10.2147/dddt.s524008

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