Article

Impact of 100 LRRK2 variants linked to Parkinson’s Disease on kinase activity and microtubule binding

2022-04-01

Abstract excerpt

Mutations enhancing the kinase activity of LRRK2 cause Parkinson’s disease (PD) and therapies that reduce LRRK2 kinase activity are being tested in clinical trials. Numerous rare variants of unknown clinical significance have been reported, but how the vast majority impact on LRRK2 function is unknown. Here, we investigate 100 LRRK2 variants linked to PD, including previously described pathogenic mutations. We ide...

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Literature Corpus work: b39293d6-810e-5f0f-a7fd-c6f890e824fa
DOI: 10.1101/2022.04.01.486724

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