Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2014

Rudenko Iakov N, Cookson Mark R

Abstract excerpt

Variation within and around the leucine-rich repeat kinase 2 (LRRK2) gene is associated with familial and sporadic Parkinson's disease (PD). Here, we discuss the prevalence of LRRK2 substitutions in different populations and their association with PD, as well as molecular and cellular mechanisms of pathologically relevant LRRK2 mutations. Kinase activation was proposed as a universal molecular mechanism for all...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neurons

Share to Parkinson Disease

Share to Protein Serine-Threonine Kinases

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24957201
DOI: 10.1007/s13311-014-0284-z
PMCID: PMC4391379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.PMID 24957201Read ↗

Clinical characteristics and pathophysiological properties of newly discovered LRRK2 variants associated with Parkinson's disease.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

Loss-of-function coding variants in the Ras of Complex Proteins/GTPase domain of Leucine Rich Repeat Kinase 2Semantic proximity Read ↗

Leucine-rich repeat kinase 2: relevance to Parkinson's disease.Semantic proximity Read ↗

Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Semantic proximity Read ↗

Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson's Disease.Semantic proximity Read ↗

LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review.Semantic proximity Read ↗

Contribution of GTPase activity to LRRK2-associated Parkinson disease.Semantic proximity Read ↗

LRRK2 pathobiology in Parkinson's disease.Semantic proximity Read ↗

LRRK2: Genetic mechanisms vs genetic subtypes.Semantic proximity Read ↗

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s DiseaseSemantic proximity Read ↗

Leucine‐rich repeat kinase 2 and Parkinson's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.