Article
Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2014
Rudenko Iakov N, Cookson Mark R
Abstract excerpt
Variation within and around the leucine-rich repeat kinase 2 (LRRK2) gene is associated with familial and sporadic Parkinson's disease (PD). Here, we discuss the prevalence of LRRK2 substitutions in different populations and their association with PD, as well as molecular and cellular mechanisms of pathologically relevant LRRK2 mutations. Kinase activation was proposed as a universal molecular mechanism for all...
Topics
- Animals
- Genetic Variation
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Neurons
- Parkinson Disease
- Protein Serine-Threonine Kinases
- Risk Factors