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Article

Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort.

Human molecular genetics - 30 Apr 2021

Bryant Nicole, Malpeli Nicole, Ziaee Julia, Blauwendraat Cornelis, Liu Zhiyong, West Andrew B

Abstract excerpt

Pathogenic missense variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified through linkage analysis in familial Parkinson disease (PD). Subsequently, other missense variants with lower effect sizes on PD risk have emerged, as well as non-coding polymorphisms (e.g. rs76904798) enriched in PD cases in genome-wide association studies. Here we leverage recent whole-genome sequences from the...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cohort Studies
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Humans

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Male

Middle Aged

Mutation, Missense

Parkinson Disease

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 33640967
DOI: 10.1093/hmg/ddab058
PMCID: PMC8101351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33640967-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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