Article

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10

2021-02-23

Abstract excerpt

Variants in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 kinase activity, supporting the therapeutic potential of LRRK2 kinase inhibitors for PD. To better understand the role of LRRK2 in disease and to support the clinical developm...

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Literature Corpus work: 2ba17c13-de8e-583c-9ff9-878c1eefe5e0
DOI: 10.1101/2021.02.23.432545

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