Article

Large-scale functional annotation establishes a reference framework for human <i>LRRK2</i> variants

2026-06-26

Abstract excerpt

Pathogenic variants in leucine-rich repeat kinase 2 ( LRRK2 ) 1 are among the most frequent monogenic causes of Parkinson’s disease (PD) 2 and act through a gain-of-function mechanism of increased kinase activity. LRRK2 -targeted therapies are in clinical development, but interpretation of the rapidly expanding catalogue of rare LRRK2 variants remains a barrier to translation. Here, we present functionally an...

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Literature Corpus work: bbe066ad-bb24-5643-ba5b-799f8719787d
DOI: 10.64898/2026.06.17.26355034

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