Article

Beyond known mutations: Functional evidence for LRRK2 pathway activation in a subset of Parkinson’s disease patients

2025-12-09

Abstract excerpt

<title>Abstract</title> Background Pathogenic <italic>LRRK2</italic> variants cause Parkinson’s disease (PD) through increased kinase activity, with <italic>VPS35</italic> p.D620N and other rare <italic>LRRK2</italic> variants showing similar effects. Findings in idiopathic PD suggest broader LRRK2 pathway involvement. As LRRK2-targeted therapies advance, identifying patients with elevated pathway acti...

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Literature Corpus work: 71cc9372-a9a4-5b24-8634-1a4df46310f3
DOI: 10.21203/rs.3.rs-8294746/v1

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