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Article

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding.

The Biochemical journal - 16 Sept 2022

Kalogeropulou Alexia F, Purlyte Elena, Tonelli Francesca, Lange Sven M, Wightman Melanie, Prescott Alan R, Padmanabhan Shalini, Sammler Esther, Alessi Dario R

Abstract excerpt

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested in clinical trials. Numerous rare variants of unknown clinical significance have been reported, but how the vast majority impact on LRRK2 function is unknown. Here, we investigate 100 LRRK2 variants linked to PD, including previously...

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Identifiers

PMID: 35950872
DOI: 10.1042/BCJ20220161
PMCID: PMC9472821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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