Article
The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease.
Cell reports - 18 Jan 2022
Qureshi Yasir H, Berman Diego E, Marsh Samuel E, Klein Ronald L, Patel Vivek M, Simoes Sabrina, Kannan Suvarnambiga, Petsko Gregory A, Stevens Beth, Small Scott A
Abstract excerpt
Disruption of retromer-dependent endosomal trafficking is considered pathogenic in late-onset Alzheimer's disease (AD). Here, to investigate this disruption in the intact brain, we turn to a genetic mouse model where the retromer core protein VPS35 is depleted in hippocampal neurons, and then we replete VPS35 using an optimized viral vector protocol. The VPS35 depletion-repletion studies strengthen the causal...
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