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Understanding the contributions of VPS35 and the retromer in neurodegenerative disease.

Neurobiology of disease - 1 Aug 2022

Williams Erin T, Chen Xi, Otero P Anthony, Moore Darren J

Abstract excerpt

Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD). Specifically, VPS35 and the retromer complex play an important role in the endolysosomal system and are implicated in the pathophysiology of these diseases. A single missense mutation in VPS35, Asp620Asn...

Topics

Alzheimer Disease
Endosomes
Humans
Mutation
Neurodegenerative Diseases
Parkinson Disease
Vesicular Transport Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35588987
DOI: 10.1016/j.nbd.2022.105768
PMCID: PMC9233057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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