Article

Retromer repletion with AAV9-VPS35 restores endosomal function in the mouse hippocampus

2019-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Retromer has emerged as a master conductor of endosomal trafficking, and VPS35 and other retromer-related proteins are found to be deficient in late-onset Alzheimer’s disease (AD). Depleting VPS35 in neurons impairs retromer function, affecting for example the trafficking of the amyloid-precursor protein (APP) and the glutamate receptor GluA1. Whether VPS35 repletion, after chronic in vivo depl...

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Literature Corpus work: 2c008110-802a-5b33-a537-2cadebde8711
DOI: 10.1101/618496

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