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VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiology

24 Aug 2020

Abstract excerpt

Mutations in VPS35 (PARK17), a key molecule in the retromer complex, are a rare cause of autosomal dominant Parkinson's disease (PD), the second most common neurodegenerative disorder. VPS35 exerts crucial functions within the cell in terms of regulating endosomal trafficking. However new data suggest its relevance also in the regulation of mitochondrial dynamics and homeostasis. Herein, we review the crosstalk...

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PMID: 32853677
DOI: 10.1016/j.nbd.2020.105056

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