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An update on cellular and molecular determinants of Parkinson's disease with emphasis on the role of the retromer complex.

Journal of neuroscience research - 1 Jan 2021

Macías-Calvio Vania, Fuentealba Luz-María, Marzolo María-Paz

Abstract excerpt

Parkinson's disease (PD) is a highly prevalent neurodegenerative condition. The disease involves the progressive degeneration of dopaminergic neurons located in the substantia nigra pars compacta. Among late-onset, familial forms of Parkinson are cases with mutations in the PARK17 locus encoding the vacuolar protein sorting 35 (Vps35), a subunit of the retromer complex. The retromer complex is composed of a...

Topics

Animals
Humans
Mutation
Parkinson Disease
Vesicular Transport Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32633426
DOI: 10.1002/jnr.24675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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