Article

Structural basis of Cdk7 activation by dual T-loop phosphorylation

2024-02-14

Abstract excerpt

Cyclin-dependent kinase 7 (Cdk7) occupies a central position in cell-cycle and transcriptional regulation owing to its function as both a CDK-activating kinase (CAK) and part of the general transcription factor TFIIH. Cdk7 forms an active complex upon association with Cyclin H and Mat1, and its catalytic activity is regulated by two phosphorylations in the activation segment (T loop): the canonical activating modi...

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Literature Corpus work: b35ed02c-64ed-5c2a-8143-5a81231cc138
DOI: 10.1101/2024.02.14.580246

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