Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

Molecular and cellular biology - 1 Aug 2009

Bockstaele Laurence, Bisteau Xavier, Paternot Sabine, Roger Pierre P

Abstract excerpt

The homologous cyclin-dependent kinases (CDK) CDK4 and CDK6 integrate mitogenic and oncogenic signaling cascades with the cell cycle. Their activation requires binding to a D-type cyclin and then T-loop phosphorylation at T172 and T177 (respectively) by the only CDK-activating kinase identified i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase 4
Share to Cyclin-Dependent Kinase 6
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclins

Share to Electrophoresis, Gel, Two-Dimensional

Share to Fluorescent Antibody Technique, Indirect

Share to HCT116 Cells

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 19487459
DOI: 10.1128/MCB.01823-08
PMCID: PMC2715811

Genes

CDK4
CDK6
CDK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19487459-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.PMID 19487459Read ↗

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.Semantic proximity Read ↗

Structural basis of Cdk7 activation by dual T-loop phosphorylationSemantic proximity Read ↗

Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.Semantic proximity Read ↗

A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase.Semantic proximity Read ↗

Recognition of Cdk2 by Cdk7.Semantic proximity Read ↗

Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.Semantic proximity Read ↗

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.Semantic proximity Read ↗

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.Semantic proximity Read ↗

Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding.Semantic proximity Read ↗

Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human CellsSemantic proximity Read ↗

Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells.Semantic proximity Read ↗

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.