Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.

The Journal of biological chemistry - 10 Nov 2000

Korsisaari N, Mäkelä T P

Abstract excerpt

Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor TFIIH, where Cdk7 phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II. Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1. This interaction was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinases
Share to Cyclins
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Histidine

Share to Precipitin Tests

Share to Protein-Tyrosine Kinases

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 10958787
DOI: 10.1074/jbc.C000505200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.PMID 10958787Read ↗

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.Semantic proximity Read ↗

Structural basis of Cdk7 activation by dual T-loop phosphorylationSemantic proximity Read ↗

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.Semantic proximity Read ↗

Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3.Semantic proximity Read ↗

The two faces of Cdk8, a positive/negative regulator of transcription.Semantic proximity Read ↗

The cryo-electron microscopy structure of the human CDK-activating kinaseSemantic proximity Read ↗

Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeast.Semantic proximity Read ↗

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.Semantic proximity Read ↗

Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p.Semantic proximity Read ↗

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.Semantic proximity Read ↗

Carboxy-terminal region of the yeast heat shock factor contains two domains that make transcription independent of the TFIIH protein kinase.Semantic proximity Read ↗

Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.