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Article

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

PLoS genetics - 1 May 2013

Bisteau Xavier, Paternot Sabine, Colleoni Bianca, Ecker Karin, Coulonval Katia, De Groote Philippe, Declercq Wim, Hengst Ludger, Roger Pierre P

Abstract excerpt

Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK). In animals, the only known CAK for CDK2 and CDK1 is cyclin H-CDK7, which is constitutively active....

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Source

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Identifiers

PMID: 23737759
DOI: 10.1371/journal.pgen.1003546
PMCID: PMC3667761

Genes

CDK4
CDK7
CDK2
CDK6
CDK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23737759-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.PMID 23737759Read ↗

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Semantic proximity Read ↗

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