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Article

Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

Nature structural & molecular biology - 1 Jun 2016

Chlamydas Sarantis, Holz Herbert, Samata Maria, Chelmicki Tomasz, Georgiev Plamen, Pelechano Vicent, Dündar Friederike, Dasmeh Pouria, Mittler Gerhard, Cadete Filipe Tavares, Ramírez Fidel, Conrad Thomas, Wei Wu, Raja Sunil, Manke Thomas, Luscombe Nicholas M, Steinmetz Lars M, Akhtar Asifa

Abstract excerpt

Proper gene expression requires coordinated interplay among transcriptional coactivators, transcription factors and the general transcription machinery. We report here that MSL1, a central component of the dosage compensation complex in Drosophila melanogaster and Drosophila virilis, displays evolutionarily conserved sex-independent binding to promoters. Genetic and biochemical analyses reveal a functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27183194
DOI: 10.1038/nsmb.3233

Genes

MSL1
CDK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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