Article

PAF1C allosterically activates CDK12/13 kinase during RNAPII transcript elongation

2024-10-16

Abstract excerpt

The mechanisms ensuring temporally correct, site-specific phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases (CDKs) during the transcription cycle remain poorly understood. Here, we present results from in vitro reconstitution of CTD phosphorylation combined with in vivo evidence to show that human CDK12 and CDK9 both co-phosphorylate CTD Serine 5 and Serine 2. However,...

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Literature Corpus work: 52848bf2-29ac-5f2a-b1e5-470123776431
DOI: 10.1101/2024.10.14.618141

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