Article

The cryo-electron microscopy structure of the human CDK-activating kinase

2020-05-13

Abstract excerpt

The human CDK-activating kinase (CAK), a complex composed of cyclin dependent kinase (CDK) 7, cyclin H, and MAT1, is a critical regulator of transcription initiation and the cell cycle. It acts by phosphorylating the C-terminal heptapeptide repeat domain of the RNA polymerase II subunit Rpb1, which is an important regulatory event in transcription initiation by Pol II, and it phosphorylates the regulatory T-loop o...

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Literature Corpus work: 816a5da7-83d9-585d-9392-5ed1c4c49e64
DOI: 10.1101/2020.05.13.094755

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