Article
The two faces of Cdk8, a positive/negative regulator of transcription.
Biochimie - 1 Feb 2014
Nemet Josipa, Jelicic Branka, Rubelj Ivica, Sopta Mary
Abstract excerpt
Three cyclin dependent kinases, Cdk7, Cdk8 and Cdk9 are intimately connected with the processes of RNA polymerase II dependent transcription initiation and elongation in eukaryotic cells. Each of these kinases is part of a larger multisubunit complex, TFIIH, Mediator and p-TEFb respectively. Of the three kinases, Cdk8 is the most complex given that it has been associated with both positive and negative effects on...
Topics
- Animals
- Cyclin-Dependent Kinase 8
- Gene Expression Regulation
- Humans
- Mutation
- Phosphorylation
- Protein Structure, Tertiary
- Schizosaccharomyces
- Signal Transduction
- Transcription Factors
- Transcription, Genetic