The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.

doi:10.1101/gad.12.22.3541

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Article

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.

Genes & development - 15 Nov 1998

Akoulitchev S, Reinberg D

Abstract excerpt

TFIIH is a multisubunit complex, containing ATPase, helicases, and kinase activities. Functionally, TFIIH has been implicated in transcription by RNA polymerase II (RNAPII) and in nucleotide excision repair. A member of the cyclin-dependent kinase family, CDK7, is the kinase subunit of TFIIH. Gen...

Topics

Amino Acid Sequence
Cell Cycle
Cyclin-Dependent Kinases
Flow Cytometry
HeLa Cells
Humans
Macromolecular Substances
Mitosis
Molecular Sequence Data
Mutation
Phosphorylation
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Saccharomyces cerevisiae Proteins

Sequence Analysis

TATA-Binding Protein Associated Factors

Transcription Factor TFIID

Transcription Factor TFIIH

Source

Open in PubMed Open full text

Identifiers

PMID: 9832506
DOI: 10.1101/gad.12.22.3541
PMCID: PMC317239

Genes

CDK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9832506-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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