Article

Multi-omic profiling of the developing human cerebral cortex at the single cell level

2022-10-17

Abstract excerpt

The cellular complexity of the human brain is established via dynamic changes in gene expression throughout development that is mediated, in part, by the spatiotemporal activity of cis-regulatory elements. We simultaneously profiled gene expression and chromatin accessibility in 45,549 cortical nuclei across 6 broad developmental time-points from fetus to adult. We identified cell-type specific domains in which ch...

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Literature Corpus work: bb54e5a5-0694-5940-b553-9001c9d666e7
DOI: 10.1101/2022.10.14.512250

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