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Article

Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development.

Cell - 4 Feb 2021

Tan Longzhi, Ma Wenping, Wu Honggui, Zheng Yinghui, Xing Dong, Chen Ritchie, Li Xiang, Daley Nicholas, Deisseroth Karl, Xie X Sunney

Abstract excerpt

Both transcription and three-dimensional (3D) architecture of the mammalian genome play critical roles in neurodevelopment and its disorders. However, 3D genome structures of single brain cells have not been solved; little is known about the dynamics of single-cell transcriptome and 3D genome after birth. Here, we generated a transcriptome (3,517 cells) and 3D genome (3,646 cells) atlas of the developing mouse...

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Identifiers

PMID: 33484631
DOI: 10.1016/j.cell.2020.12.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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