Article

In-Depth Mapping of DNA-PKcs Signaling Uncovers Conserved Features of Its Kinase Specificity

2024-01-20

Abstract excerpt

<h4>ABSTRACT</h4> DNA-PKcs is a DNA damage sensor kinase with established roles in DNA double-strand break repair via non-homologous end joining. Recent studies have revealed additional roles of DNA-PKcs in the regulation of transcription, translation and DNA replication. However, the substrates through which DNA-PKcs regulates these processes remain largely undefined. Here we utilized quantitative phosphoproteom...

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Literature Corpus work: b3321ed8-ffe2-5949-a77a-7b8c6d047d71
DOI: 10.1101/2024.01.17.576037

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