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Article

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment.

1 Jun 2012

Abstract excerpt

DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of the non-homologous end-joining (NHEJ) pathway, is involved in DNA double-strand break repair, immunocompetence, genomic integrity, and epidermal growth factor receptor signaling. Clinical studies indicate that expression and activity of DNA-PKcs is correlated with cancer progression and response to treatment. Various anti-DNA-PKcs...

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PMID: 22943041
DOI: 10.3978/j.issn.2218-676x.2012.04.01

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