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Structural insights into the role of DNA-PK as a master regulator in NHEJ

23 Jul 2021

Abstract excerpt

is the largest serine/threonine protein kinase of the phosphatidyl inositol 3-kinase-like protein kinase (PIKK) family and is the most highly expressed PIKK in human cells. With its DNA-binding partner Ku70/80, DNA-PKcs is required for regulated and efficient repair of ionizing radiation-induced DNA double-strand breaks via the non-homologous end joining (NHEJ) pathway. Loss of DNA-PKcs or other NHEJ factors...

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PMID: 34723130
DOI: 10.1007/s42764-021-00047-w

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