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Article

DNA-PKcs and ATM co-regulate DNA double-strand break repair.

DNA repair - 6 Aug 2009

Shrivastav Meena, Miller Cheryl A, De Haro Leyma P, Durant Stephen T, Chen Benjamin P C, Chen David J, Nickoloff Jac A

Abstract excerpt

DNA double-strand breaks (DSBs) are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR). The NHEJ/HR decision is under complex regulation and involves DNA-dependent protein kinase (DNA-PKcs). HR is elevated in DNA-PKcs null cells, but suppressed by DNA-PKcs kinase inhibitors, suggesting that kinase-inactive DNA-PKcs (DNA-PKcs-KR) would suppress HR. Here we use a direct repeat assay to...

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Source

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Identifiers

PMID: 19535303
DOI: 10.1016/j.dnarep.2009.05.006
PMCID: PMC3071034

Genes

ATM
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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