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Article

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

Cancer discovery - 1 May 2014

Dietlein Felix, Thelen Lisa, Jokic Mladen, Jachimowicz Ron D, Ivan Laura, Knittel Gero, Leeser Uschi, van Oers Johanna, Edelmann Winfried, Heukamp Lukas C, Reinhardt H Christian

Abstract excerpt

Here, we use a large-scale cell line-based approach to identify cancer cell-specific mutations that are associated with DNA-dependent protein kinase catalytic subunit (DNA-PKcs) dependence. For this purpose, we profiled the mutational landscape across 1,319 cancer-associated genes of 67 distinct...

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Topics

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Share to Cell Line, Tumor
Share to Colonic Neoplasms
Share to DNA-Activated Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MutS Homolog 3 Protein

Share to Neoplasms, Experimental

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Source

Identifiers

PMID: 24556366
DOI: 10.1158/2159-8290.CD-13-0907

Genes

MSH3
ATM
BRCA1
BRCA2
PRKDC
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24556366-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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