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DNA double-strand break signaling and human disorders

1 Jan 2010

Abstract excerpt

DNA double-strand breaks are among the most serious types of DNA damage and their signaling and repair is critical for all cells and organisms. The repair of both induced and programmed DNA breaks is fundamental as demonstrated by the many human syndromes, neurodegenerative diseases, immunodeficiency and cancer associated with defective repair of these DNA lesions. Homologous recombination and non-homologous...

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PMID: 21054854
DOI: 10.1186/2041-9414-1-15

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