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Activation of DNA damage response signaling in mammalian cells by ionizing radiation

18 Jan 2021

Abstract excerpt

Cellular responses to DNA damage are fundamental to preserve genomic integrity during various endogenous and exogenous stresses. Following radiation therapy and chemotherapy, this DNA damage response (DDR) also determines development of carcinogenesis and therapeutic outcome. In humans, DNA damage activates a robust network of signal transduction cascades, driven primarily through phosphorylation events. These...

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PMID: 33455476
DOI: 10.1080/10715762.2021.1876853

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