Article

Early epigenetic influence on EGR1, KLF2 and KLF4 transcriptional network associates with alteration of HSCs quiescence

2021-10-24

Abstract excerpt

<h4>Summary</h4> Excessive fetal growth is associated with DNA methylation alterations in human hematopoietic stem and progenitor cells (HSPC), but their functional impact remains elusive. We implemented an integrative analysis combining single-cell epigenomics, single-cell transcriptomics, and in vitro analyses to functionally link DNA methylation changes to putative alterations of HSPC functions. We showed in...

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Literature Corpus work: b32f0cf3-73d1-5a70-9ef5-8f5cdbc512c8
DOI: 10.1101/2021.10.22.465419

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Early epigenetic influence on EGR1, KLF2 and KLF4 transcriptional network associates with alteration of HSCs quiescenceDOI 10.1101/2021.10.22.465419Read

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