Article

Cross-tissue patterns of DNA hypomethylation reveal genetically distinct histories of cell development

2022-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Establishment of DNA methylation (DNAme) patterns is essential for balanced multi-lineage cellular differentiation, but exactly how these patterns drive cellular phenotypes is unclear. While >80% of CpG sites are stably methylated, tens of thousands of discrete CpG loci form hypomethylated regions (HMRs). Because they lack DNAme, HMRs are considered transcriptionally permissive, but not all HMRs...

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Literature Corpus work: 765c80d7-0656-59be-8b40-7245a6251f7a
DOI: 10.1101/2022.12.15.520535

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