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Article

Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction

25 Jan 2010

Abstract excerpt

BACKGROUND: Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g., type 2 diabetes mellitus; T2DM), manifesting as late as decades later. We hypothesized that this biological memory is mediated by permanent alterations of the epigenome in stem cell populations, and focused our...

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PMID: 20126273
DOI: 10.1371/journal.pone.0008887

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