X Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Abstract excerpt

<h4>ABSTRACT</h4> During early mammalian development, the two X-chromosomes in female cells are active. Dosage compensation between XX female and XY male cells is then achieved by X-chromosome inactivation in female cells. Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female i...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• DNA Copy Number Variations
• Embryonic Stem Cells
• Gene Knockdown Techniques
• Genes, X-Linked
• MAP Kinase Signaling System
• Sex Characteristics
• X Chromosome

Identifiers and source

Literature Corpus work

b31b179a-d9e8-5e91-b928-baefb70e16ba

DOI

10.1101/291450