Article

Induction of X-chromosome Inactivation by the Histone Demethylase SMCX/KDM5C

2017-08-11

Abstract excerpt

<h4>SUMMARY</h4> XY male and XX female mammals equalize X-linked gene expression through the mitotically-stable transcriptional inactivation of an X-chromosome in females. Although most genes are silent on the inactive-X, some escape silencing and are expressed at higher levels in females vs. males. Here, we show that the escapee Smcx / Kdm5c , encoding a histone H3K4me2/3 demethylase, underlies the female-spe...

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Literature Corpus work: abb888ac-5d4b-5fb3-959c-71ecc9a24c59
DOI: 10.1101/175174

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