Article

ALS Motor Neurons Exhibit Hallmark Metabolic Defects That Are Rescued by Nicotinamide and SIRT3 Activation

2019-08-02

Abstract excerpt

<h4>SUMMARY</h4> Motor neurons (MNs) are highly energetic cells and recent studies suggest that altered energy metabolism precede MN loss in Amyotrophic Lateral Sclerosis (ALS), an age-onset neurodegenerative disease. However, clear mechanistic insights linking altered metabolism and MN death are still missing. In this study, induced pluripotent stem cells (iPSCs) from healthy controls, familial ALS and sporadic...

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Literature Corpus work: 604fc699-48a6-5aec-adc6-6e7d0405d59b
DOI: 10.1101/713651

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