Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction.

doi:10.1371/journal.pone.0025823

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Article

Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction.

PloS one - 1 Jan 2011

Celotto Alicia M, Chiu Wai Kan, Van Voorhies Wayne, Palladino Michael J

Abstract excerpt

Numerous mitochondrial DNA mutations cause mitochondrial encephalomyopathy: a collection of related diseases for which there exists no effective treatment. Mitochondrial encephalomyopathies are complex multisystem diseases that exhibit a relentless progression of severity, making them both difficult to treat and study. The pathogenic and compensatory metabolic changes that are associated with chronic...

Topics

Animals
Behavior, Animal
Cell Respiration
Citric Acid Cycle
Disease Models, Animal
Disease Progression
Drosophila
Drosophila Proteins
Electron Transport
Energy Metabolism
Glycolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Longevity

Mitochondrial Diseases

Mitochondrial Proton-Translocating ATPases

Models, Biological

Phenotype

Protein Multimerization

Source

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Identifiers

PMID: 21991365
DOI: 10.1371/journal.pone.0025823
PMCID: PMC3185040

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