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Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons.

Cells - 9 May 2023

Zimyanin Vitaly L, Pielka Anna-Maria, Glaß Hannes, Japtok Julia, Großmann Dajana, Martin Melanie, Deussen Andreas, Szewczyk Barbara, Deppmann Chris, Zunder Eli, Andersen Peter M, Boeckers Tobias M, Sterneckert Jared, Redemann Stefanie, Storch Alexander, Hermann Andreas

Abstract excerpt

Motoneurons are one of the most energy-demanding cell types and a primary target in Amyotrophic lateral sclerosis (ALS), a debilitating and lethal neurodegenerative disorder without currently available effective treatments. Disruption of mitochondrial ultrastructure, transport, and metabolism is a commonly reported phenotype in ALS models and can critically affect survival and the proper function of motor...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37408187
DOI: 10.3390/cells12101352
PMCID: PMC10216752

Genes

FUS

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