Article

Mechanical plasticity of the ECM directs invasive branching morphogenesis in human mammary gland organoids

2019-11-29

Abstract excerpt

Although branching morphogenesis is central for organogenesis in diverse organs, the underlying self-organizing principles have yet to be identified. Here, we show that invasive branching morphogenesis in human mammary organoids relies on an intricate tension-driven feedback mechanism, which is based on the nonlinear and plastic mechanical response of the surrounding collagen network. Specifically, we demonstrate...

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Literature Corpus work: b2dd0296-6be5-5097-aca8-e7d930dc94b8
DOI: 10.1101/860015

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