Article
Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell-extracellular matrix mechanical feedback.
Nature materials - 1 Jun 2025
Alisafaei Farid, Shakiba Delaram, Hong Yuan, Ramahdita Ghiska, Huang Yuxuan, Iannucci Leanne E, Davidson Matthew D, Jafari Mohammad, Qian Jin, Qu Chengqing, Ju David, Flory Dashiell R, Huang Yin-Yuan, Gupta Prashant, Jiang Shumeng, Mujahid Aliza, Singamaneni Srikanth, Pryse Kenneth M, Chao Pen-Hsiu Grace, Burdick Jason A, Lake Spencer P, Elson Elliot L, Huebsch Nathaniel, Shenoy Vivek B, Genin Guy M
Abstract excerpt
Mechanical factors such as stress in the extracellular environment affect the phenotypic commitment of cells. Stress fields experienced by cells in tissues are multiaxial, but how cells integrate such information is largely unknown. Here we report that the anisotropy of stress fields is a critical factor triggering a phenotypic transition in fibroblast cells, outweighing the role of stress amplitude, a factor...
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