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Article

Mechanical compression drives cancer cells toward invasive phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2012

Tse Janet M, Cheng Gang, Tyrrell James A, Wilcox-Adelman Sarah A, Boucher Yves, Jain Rakesh K, Munn Lance L

Abstract excerpt

Uncontrolled growth in a confined space generates mechanical compressive stress within tumors, but little is known about how such stress affects tumor cell behavior. Here we show that compressive stress stimulates migration of mammary carcinoma cells. The enhanced migration is accomplished by a subset of "leader cells" that extend filopodia at the leading edge of the cell sheet. Formation of these leader cells is...

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Source

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Identifiers

PMID: 22203958
DOI: 10.1073/pnas.1118910109
PMCID: PMC3271885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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