Article

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

2021-10-25

Abstract excerpt

Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large mechanical forces. To better understand the mechanisms that coordinate human muscle morphogenesis from tissue to molecular scales, we adopted a simple in vitro system using induce...

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Literature Corpus work: 2626e938-32a1-5ff7-9624-783657d44b1a
DOI: 10.1101/2021.10.24.465614

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