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Mapping the structure and biological functions within mesenchymal bodies using microfluidics

4 Mar 2020

Abstract excerpt

Organoids that recapitulate the functional hallmarks of anatomic structures comprise cell populations able to self-organize cohesively in 3D. However, the rules underlying organoid formation in vitro remain poorly understood because a correlative analysis of individual cell fate and spatial organization has been challenging. Here, we use a novel microfluidics platform to investigate the mechanisms determining the...

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PMID: 32181333
DOI: 10.1126/sciadv.aaw7853

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