Article

Mechanically primed cells transfer memory to fibrous matrices for persistent invasion

2022-05-02

Abstract excerpt

In disease and development, cells sense and migrate across mechanically dissimilar environments. We investigated whether mechanical memory of past environments empowers cells to navigate new, three-dimensional environments. Here, we show that cells primed by stiff matrices apply higher forces, compared to soft-primed cells, to accumulate and align collagen fibers towards sustained invasion. This priming advantage...

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Literature Corpus work: 61f3f526-f59d-5679-bcb8-03bb7caf7bee
DOI: 10.1101/2022.05.02.490316

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