Article

Cell based strain stiffening of a non-fibrous matrix as organizing principle for morphogenesis

2019-10-24

Abstract excerpt

Endothelial tube formation on a reconstituted extracellular matrix (Matrigel) is a well-established in vitro model for studying the processes of angiogenesis and vasculogenesis. However, to date, the organizing principles that underlie the morphogenesis of this network, and that shape the initial process of cell-cell finding remain elusive. Furthermore, it is unclear how in vitro results extrapolate to in vivo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f710d58-9b8c-515e-a2ea-92205d336fe9
DOI: 10.1101/816496

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell based strain stiffening of a non-fibrous matrix as organizing principle for morphogenesisDOI 10.1101/816496Read

Extracellular matrix flow guides emergent in-vitro morphogenesisSemantic proximity Read

Endothelial cell motility, coordination and pattern formation during vasculogenesisSemantic proximity Read

The extracellular matrix mechanics in the vasculature.Semantic proximity Read

Non-Elastic Remodeling of the 3D Extracellular Matrix by Cell-Generated ForcesSemantic proximity Read

Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic RemodellingSemantic proximity Read

4D force patterning enables spatial control of angiogenesisSemantic proximity Read

Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delaminationSemantic proximity Read

Matrix stiffness-induced transcriptome alterations and regulatory mechanisms revealed by RNA-seq in Endothelial cellsSemantic proximity Read

Architectural Dynamics in Living Tissues: Integrating Structure, Physical Fields and Spatial NetworksSemantic proximity Read

Topology of connective tissues: a key parameter in cellular heterogeneity, beyond composition and stiffnessSemantic proximity Read

Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivoSemantic proximity Read

It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with MechanobiologySemantic proximity Read