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A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

7 Jun 2024

Abstract excerpt

Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristics and express the myoepithelial/basal cell marker Keratin 14 (K14). Emergence of leader cells and K14 expression are regarded as interconnected events triggered by Collagen I,...

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PMID: 38849373
DOI: 10.1038/s41467-024-49230-z

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