Article

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

2023-11-02

Abstract excerpt

<h4>ABSTRACT</h4> RNA polymerase II (RNAPII) transcription initiates bidirectionally at many human protein-coding genes. Sense transcription usually dominates and leads to messenger RNA production, whereas antisense transcription rapidly terminates. The basis for this directionality is not fully understood. Here, we show that sense transcriptional initiation is more efficient than in the antisense direction, whic...

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Literature Corpus work: b2c05f45-c722-5b59-8bb1-c6fc722e6c0c
DOI: 10.1101/2023.11.02.565285

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