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Article

Gene loops enhance transcriptional directionality.

Science (New York, N.Y.) - 2 Nov 2012

Tan-Wong Sue Mei, Zaugg Judith B, Camblong Jurgi, Xu Zhenyu, Zhang David W, Mischo Hannah E, Ansari Aseem Z, Luscombe Nicholas M, Steinmetz Lars M, Proudfoot Nick J

Abstract excerpt

Eukaryotic genomes are extensively transcribed, forming both messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). ncRNAs made by RNA polymerase II often initiate from bidirectional promoters (nucleosome-depleted chromatin) that synthesize mRNA and ncRNA in opposite directions. We demonstrate that,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23019609
DOI: 10.1126/science.1224350
PMCID: PMC3563069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23019609-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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