Article

Dynamics and Topology of Human Transcribed <i>Cis</i> -regulatory Elements

2019-07-03

Abstract excerpt

Promoters and enhancers are key cis -regulatory elements, but how they orchestrate to generate cell-type-specific transcriptomes remains elusive. We developed a simple and robust approach to globally determine 5’-ends of nascent RNAs (NET-CAGE) in diverse cells and tissues, thereby sensitively detecting unstable transcripts including enhancer-derived RNAs. We studied RNA synthesis and degradation at the transcrip...

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Literature Corpus work: 2a913042-26f6-50b9-a0fa-d72f758dea44
DOI: 10.1101/689968

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